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Introducing in vitro metabolism as a powerful tool in the identification of pesticide metabolites
Analytical phases of metabolism studies are performed in our laboratories by expert and experienced staff. Total radioactive residue, extractions, matrix clean-up, isolations, and characterization / radioprofiles of the incurred residue are tailored and performed to satisfy routine and challenging projects with exceptional care and quality.
Elucidating the structure of novel metabolites is often technically challenging and requires the attention of experienced metabolite ID chemists. Our laboratories contain advanced chromatographic and mass spectrometry equipment, which provide an efficient metabolite profiling and identification service.
Crop studies are conducted to determine the nature and amount of pesticide residue in crops. Our plant metabolism experts conduct in-life phase on site in our greenhouses or in the field with trusted partner sites.
We conduct the in-life phase of animal metabolism studies, in cow, goat, and poultry, at partner facilities. We work with sponsors to design and plan every detail of a study to best meet the product development and/or regulatory compliance needs.
In vitro metabolism
Use of in vitro studies to provide comparative metabolism information is a powerful tool that is both faster and more cost effective than in vivo studies. Smithers is at the forefront of both exploratory and regulated in vitro approaches for both plants and animals.