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Bioaccumulation in Fish
Aqueous bioconcentration studies are conducted to assess a chemical’s bioconcentration factor (BCF) in fish. Fish are exposed to the chemical dissolved in water and the BCF is calculated as the ratio of the concentration in the fish to the dissolved concentration in water at steady-state, or by the ratio of the uptake and depuration rate constants. For poorly soluble substances where stable and measurable concentrations are difficult to obtain, bioaccumulation can be assessed using spiked feed, resulting in a dietary biomagnification factor or BMF. Kinetic BCF (BCFk) can be estimated from a BMF study, where fish and fish food are collected and analyzed during the test.
Bioaccumulation in Sediment-dwelling Benthic Oligochaetes
Designed to assess bioaccumulation of sediment-associated chemicals in endobenthic oligochaetes. Test organisms are exposed to chemicals via multiple uptake routes, including direct ingestion of sediment, surface contact and ingestion of pore water. Oligochaetes, sediment and overlying water samples are collected analyzed at specified intervals. The primary endpoints are a bioaccumulation factor (BAF) and a biota-sediment accumulation factor (BSAF).
Bioaccumulation in Terrestrial Oligochaetes
Designed to assess bioaccumulation of chemicals in terrestrial oligochaetes, test organisms are exposed to soil dosed with the test chemicals and oligochaetes and soil are collected and analyzed at intervals. The primary endpoints are a BAF and a biota-soil accumulation factor (BSAF).